Renal function decreases at age 75 by what percent?

Renal function decreases at age 75 by what percent?

• A. 25%
• B. 75%
• C. 50%
• D. 10%

Answer: (B)

Aging kidneys lose nephrons, shrink in mass, and receive less blood flow, so the GFR steadily falls over time. By about age 75, the combined effect of these changes is a substantial drop in overall renal function compared with young adults. In many pharmacology references used for exams, this is stated as roughly a 75% decrease from young-adult baseline. Recognizing this large decline helps explain why drug dosing often needs adjustment in older patients: renal clearance is markedly reduced, raising the risk of drug buildup and toxicity if standard doses are kept. Other percentages would underestimate the extent of age-related renal decline typically taught for this topic.

Aging kidneys lose nephrons, shrink in mass, and receive less blood flow, so the GFR steadily falls over time. By about age 75, the combined effect of these changes is a substantial drop in overall renal function compared with young adults. In many pharmacology references used for exams, this is stated as roughly a 75% decrease from young-adult baseline. Recognizing this large decline helps explain why drug dosing often needs adjustment in older patients: renal clearance is markedly reduced, raising the risk of drug buildup and toxicity if standard doses are kept. Other percentages would underestimate the extent of age-related renal decline typically taught for this topic.